Quantification of dsDNA functionalization efficiency in THz biosensors

Weisenstein C, Schmeck M, Schaar D, Wigger AK, Boßerhoff AK, Bolivar PH (2019)

Publication Type: Conference contribution

Publication year: 2019

Publisher: IEEE Computer Society

Book Volume: 2019-September

Conference Proceedings Title: International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz

Event location: Paris FR

ISBN: 9781538682852

DOI: 10.1109/IRMMW-THz.2019.8873759

Abstract

In the past, THz bioanalytical techniques have been proven to be viable tools for label-free detection of biomolecules. However, significant improvements in the detection limit are needed to apply THz biosensors in biomedical diagnosis. To determine detection limits of the biosensor and the absolute amount of sample volume, quantitative measurements are required. We present label-free THz sensing of dsDNA and implement an approach based on reference investigations to quantify the dsDNA functionalization density. Defined functionalization densities are vital to maximize the adsorption of a dsDNA groove-binding protein, which acts as a tumor marker for malignant melanoma.

Authors with CRIS profile

Dominik Schaar Lehrstuhl für Biochemie und Molekulare Medizin Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Universität Siegen DE Germany (DE)

How to cite

APA:

Weisenstein, C., Schmeck, M., Schaar, D., Wigger, A.K., Boßerhoff, A.K., & Bolivar, P.H. (2019). Quantification of dsDNA functionalization efficiency in THz biosensors. In International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz. Paris, FR: IEEE Computer Society.

MLA:

Weisenstein, C., et al. "Quantification of dsDNA functionalization efficiency in THz biosensors." Proceedings of the 44th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2019, Paris IEEE Computer Society, 2019.

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