Bernkopf D, Behrens J (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 5
Journal Issue: 3
DOI: 10.1080/23723556.2018.1458015
Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and dephosphorylates AXIN1-bound β-catenin (CTNNB1) thereby activating Wnt/β-catenin signaling. Because Wnt/β-catenin signaling induces mitochondrial biogenesis dysfunctional mitochondria trigger their own replacement by releasing PGAM5.
APA:
Bernkopf, D., & Behrens, J. (2018). Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling. Molecular & Cellular Oncology, 5(3). https://doi.org/10.1080/23723556.2018.1458015
MLA:
Bernkopf, Dominic, and Jürgen Behrens. "Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling." Molecular & Cellular Oncology 5.3 (2018).
BibTeX: Download