The Role of Autoantibodies in Bone Metabolism and Bone Loss
Hauser B, Harre U (2018)
Publication Type: Journal article, Review article
Publication year: 2018
Journal
Book Volume: 102
Pages Range: 522-532
Journal Issue: 5
DOI: 10.1007/s00223-017-0370-4
Abstract
Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells. Furthermore, we summarize the current knowledge about neutralizing antibodies to the antiresorptive protein osteoprotegerin, which have been described in patients with Coeliac Disease, Rheumatoid Arthritis, and Spondyloarthritis.
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United Kingdom (GB)How to cite
APA:
Hauser, B., & Harre, U. (2018). The Role of Autoantibodies in Bone Metabolism and Bone Loss. Calcified Tissue International, 102(5), 522-532. https://dx.doi.org/10.1007/s00223-017-0370-4
MLA:
Hauser, Barbara, and Ulrike Harre. "The Role of Autoantibodies in Bone Metabolism and Bone Loss." Calcified Tissue International 102.5 (2018): 522-532.
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