Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study
Fiedler M, Renner P, Schubert J, Weber F, Hartmann A, Iro H, Vielsmeier V, Bohr C, Gerken M, Reichert TE, Ettl T (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 23
Pages Range: 3801-3809
Journal Issue: 10
DOI: 10.1007/s00784-019-02809-z
Abstract
Objectives: The aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas. Material and methods: Immunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined. Results: Expression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%), and SCC (100%). In the totality of tumors, loss of FHIT expression was found in 46.7% (106/227) and was significantly associated with advanced T stage and UICC stage, high-grade histology, loss of p27, PI3K, and survivin. FHIT positivity went along with significantly better overall and disease-specific survival. Negativity of p27 occurred in 28.7% (70/244) of tumors, particularly in SDC (54.4%) and SCC (50%). In the totality of tumors, p27 was associated with advanced patient age, high-grade histology, PI3K, survivin as well as better overall and disease-specific survival (p < 0.05). Positive pERK1/ERK2 expression correlated with positive survivin expression but did not affect overall survival in the totality of tumors. In mucoepidermoid carcinomas, pERK1/ERK2 expression was associated with low-grade malignancy, positive nuclear survivin, and better disease-specific survival. Conclusions: Loss of FHIT and p27 characterizes aggressive tumor growth and unfavorable prognosis in salivary gland cancer. Clinical relevance: The results may help to stratify patient-specific therapies according to individual tumor characteristics.
Authors with CRIS profile
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Heinrich Iro
Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde
Involved external institutions
Germany (DE)How to cite
APA:
Fiedler, M., Renner, P., Schubert, J., Weber, F., Hartmann, A., Iro, H.,... Ettl, T. (2019). Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study. Clinical Oral Investigations, 23(10), 3801-3809. https://doi.org/10.1007/s00784-019-02809-z
MLA:
Fiedler, Mathias, et al. "Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study." Clinical Oral Investigations 23.10 (2019): 3801-3809.
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