T cells as key players for bone destruction in gouty arthritis?

Harre U, Derer A, Schorn C, Schett G, Herrmann M (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Arthritis Research & Therapy BioMed Central

Book Volume: 13

Article Number: 135

Journal Issue: 6

DOI: 10.1186/ar3508

Abstract

The deposition of monosodium urate (MSU) crystals in synovial fluid and tissue leads to gouty arthritis frequently associated with synovial inflammation and bone erosions. The cellular mechanism that links MSU crystals to an increased number of osteoclasts has not yet been fully understood. In a recent issue of Arthritis Research & Therapy Lee and colleagues proposed that bone destruction in chronic gouty arthritis is at least in part dependent on expression by T cells of receptor activator of NF-κB ligand (RANKL). The authors showed that pro-resorptive cytokines such as IL-1β, IL-6, and TNFα are expressed within tophi and stromal infiltrates. In vitro stimulation with MSU crystals revealed monocytes as a source for these cytokines, whereas T cells produce RANKL, the major trigger of osteoclastogenesis. © 2011 BioMed Central Ltd.

Authors with CRIS profile

Ulrike Steffen Department of Medicine 3 – Rheumatology and Immunology Anja Derer Einrichtungen, die zum Universitätsklinikum Erlangen gehören Christine Schorn Lehrstuhl für Genetik Georg Schett Lehrstuhl für Innere Medizin III Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Harre, U., Derer, A., Schorn, C., Schett, G., & Herrmann, M. (2011). T cells as key players for bone destruction in gouty arthritis? Arthritis Research & Therapy, 13(6). https://doi.org/10.1186/ar3508

MLA:

Harre, Ulrike, et al. "T cells as key players for bone destruction in gouty arthritis?" Arthritis Research & Therapy 13.6 (2011).

BibTeX: Download