Epigenetic regulation of p21cip1/waf1 in human cancer

Ocker M, Al Bitar S, Monteiro A, Gali-Muhtasib H, Schneider-Stock R (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Cancers MDPI

Book Volume: 11

Article Number: 1343

Journal Issue: 9

DOI: 10.3390/cancers11091343

Abstract

p21^cip1/waf1 is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter hypermethylation as well as additional pathways such as histone acetylation or methylation. The epigenetic regulators include writers, such as DNA methyltransferases (DNMTs); histone acetyltransferases (HATs) and histone lysine methyltransferases; erasers, such as histone deacetylases (HDACs); histone lysine demethylases [e.g., the Lysine Demethylase (KDM) family]; DNA hydroxylases; readers, such as the methyl-CpG-binding proteins (MBPs); and bromodomain-containing proteins, including the bromo-and extraterminal domain (BET) family. We further discuss the roles that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play in the epigenetic control of p21^cip1/waf1 expression and its function in human cancers.

Authors with CRIS profile

Ana Monteiro Professur für Experimentelle Tumorpathologie Regine Schneider-Stock Professur für Experimentelle Tumorpathologie

Involved external institutions

Bayer AG

Germany (DE) American University of Beirut (AUB) / الجامعة الأميركية في بيروت‎‎

Lebanon (LB)

How to cite

APA:

Ocker, M., Al Bitar, S., Monteiro, A., Gali-Muhtasib, H., & Schneider-Stock, R. (2019). Epigenetic regulation of p21cip1/waf1 in human cancer. Cancers, 11(9). https://doi.org/10.3390/cancers11091343

MLA:

Ocker, Matthias, et al. "Epigenetic regulation of p21cip1/waf1 in human cancer." Cancers 11.9 (2019).

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