Now i am ready - Now i am not: The influence of pre-TMS oscillations and corticomuscular coherence on motor-evoked potentials

Schulz H, Uebelacker T, Keil J, Müller N, Weisz N (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Cerebral Cortex Oxford University Press

Book Volume: 24

Pages Range: 1708-1719

Journal Issue: 7

DOI: 10.1093/cercor/bht024

Abstract

There is a growing body of research on the functional role of oscillatory brain activity. However, its relation to functional connectivity has remained largely obscure. In the sensorimotor system, movement-related changes emerge in the α (8-14 Hz) and β (15-30 Hz) range (event-related desynchronization, ERD, before and during movement; event-related synchronization, ERS, after movement offset). Some studies suggest that β-ERS may functionally inhibit new movements. According to the gating-by-inhibition framework (Jensen and Mazaheri 2010), we expected that the ERD would go along with increased corticomuscular coupling, and vice versa. By combining transcranial magnetic stimulation (TMS) and electroencephalography, we were directly able to test this hypothesis. In a reaction time task, single TMS pulses were delivered randomly during ERD/ERS to the motor cortex. The motor-evoked potential (MEP) was then related to the β and α frequencies and corticomuscular coherence. Results indicate that MEPs are smaller when preceded by high pre-TMS β-band power and low pre-TMS α-band corticomuscular coherence (and vice versa) in a network of motor-relevant areas comprising frontal, parietal, and motor cortices. This confirms that an increase in rhythms that putatively reflect functionally inhibited states goes along with weaker coupling of the respective brain regions. © 2013 The Author. Published by Oxford University Press. All rights reserved.

Authors with CRIS profile

Nadia Müller-Voggel

Involved external institutions

Universität Konstanz DE Germany (DE) Università degli Studi di Trento IT Italy (IT) Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Schulz, H., Uebelacker, T., Keil, J., Müller, N., & Weisz, N. (2014). Now i am ready - Now i am not: The influence of pre-TMS oscillations and corticomuscular coherence on motor-evoked potentials. Cerebral Cortex, 24(7), 1708-1719. https://dx.doi.org/10.1093/cercor/bht024

MLA:

Schulz, Hannah, et al. "Now i am ready - Now i am not: The influence of pre-TMS oscillations and corticomuscular coherence on motor-evoked potentials." Cerebral Cortex 24.7 (2014): 1708-1719.

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