Programmable Hierarchical Construction of Mixed/Multilayered Polysaccharide Nanocapsules through Simultaneous/Sequential Nanoprecipitation Steps
Yan X, Ramos RANS, Alcouffe P, Munoz LE, Bilyy RO, Ganachaud F, Bernard J (2019)
Publication Type: Journal article
Publication year: 2019
Journal
DOI: 10.1021/acs.biomac.9b00990
Abstract
We report here on a one-pot construction of oil-filled hierarchical capsular assemblies using the nanoprecipitation technique. Relying on multicomponent phase diagrams, we show that simultaneous and/or sequential nanoprecipitations involving polymer combinations can be precisely programmed to design a new class of mixed/multilayered multicomponent nanocapsules, with a precise control of the dimensions, shell thickness/composition, and spatial distribution of the building blocks. The simplicity and tunability of this approach are exemplified here with a library of neutral and ionic polysaccharides giving access to a range of functional multilayered nanocarriers of interest for biomedical applications.
Authors with CRIS profile
Involved external institutions
Tianjin University (TJU) / 天津大学
China (CN)
Université de Lyon (UDL)
France (FR)
Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького
Ukraine (UA)
China (CN)
Université de Lyon (UDL)
France (FR)
Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького
Ukraine (UA)
How to cite
APA:
Yan, X., Ramos, R.A.N.S., Alcouffe, P., Munoz, L.E., Bilyy, R.O., Ganachaud, F., & Bernard, J. (2019). Programmable Hierarchical Construction of Mixed/Multilayered Polysaccharide Nanocapsules through Simultaneous/Sequential Nanoprecipitation Steps. Biomacromolecules. https://doi.org/10.1021/acs.biomac.9b00990
MLA:
Yan, Xibo, et al. "Programmable Hierarchical Construction of Mixed/Multilayered Polysaccharide Nanocapsules through Simultaneous/Sequential Nanoprecipitation Steps." Biomacromolecules (2019).
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