Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah PDP, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W, Alicia BFJ, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Barrdahl M, Baynes C, Freeman LEB, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Brinton L, Broberg P, Brucker SY, Bruning T, Burwinkel B, Cai Q, Caldes T, Canzian F, Carter BD, Castelao JE, Chang-Claude J, Chenevix-Trench G, Cheng TYD, Clarke CL, Conroy DM, Couch FJ, Cox DG, Cox A, Cross SS, Cunningham JM, Czene K, Daly MB, Doheny KF, Dork T, Dos-Santos-Silva I, Dumont M, Dunning AM, Dwek M, Earp HS, Eccles DM, Eliassen AH, Engel C, Eriksson M, Evans DG, Fachal L, Fasching PA, Figueroa J, Fletcher O, Flyger H, Fritschi L, Gabrielson M, Gago-Dominguez M, Gapstur SM, Garcia-Closas M, Gaudet MM, Ghoussaini M, Giles GG, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Guenel P, Hahnen E, Haiman CA, Hakansson N, Hall P, Hallberg E, Hamann U, Harrington P, He W, Hein A, Hicks B, Hillemanns P, Hogervorst FB, Hollestelle A, Hoover RN, Hopper JL, Howell A, Huang G, Jakubowska A, Janni W, John EM, Johnson N, Jones K, Jung A, Kaaks R, Kabisch M, Kerin MJ, Khusnutdinova E, Kitahara CM, Kosma VM, Koutros S, Kraft P, Kristensen VN, Lambrechts D, Le Marchand L, Lindstrom S, Linet MS, Lissowska J, Loibl S, Lubinski J, Luccarini C, Lux MP, Maishman T, Kostovska IM, Mannermaa A, Manoukian S, Manson JE, Margolin S, Mavroudis D, Meijers-Heijboer H, Meindl A, Menon U, Meyer J, Mulligan AM, Neuhausen SL, Nevanlinna H, Neven P, Newman WT, Nielsen SF, Nordestgaard BG, Olopade OI, Olshan AF, Olson JE, Olsson H, Olswol C, Orr N, Perou CM, Peto J, Plaseska-Karanfilska D, Prentice R, Presneau N, Pylkas K, Rack B, Radice P, Rahman N, Rennert G, Rennert HS, Romero A, Romm J, Saloustros E, Sandler DP, Sawyer EJ, Schmutzler RK, Schneeweiss A, Scott RJ, Scott C, Seal S, Seynaeve C, Smeets A, Southey MC, Spinelli JJ, Stone J, Surowy H, Swerdlow AJ, Tamimi R, Tapper W, Taylor JA, Terry MB, Tessier DC, Thone K, Tollenaar RAEM, Torres D, Troester MA, Truong T, Untch M, Vachon C, Van Den Berg D, Van Den Ouweland AMW, Van Veen EM, Vincent D, Waisfisz Q, Weinberg CR, Wendt C, Whittemore AS, Wildiers H, Winqvist R, Wolk A, Xia L, Yang XR, Ziogas A, Ziv E (2019)


Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 48

Pages Range: 795-806

Journal Issue: 3

DOI: 10.1093/ije/dyy201

Abstract

Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear.

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How to cite

APA:

Shu, X., Wu, L., Khankari, N.K., Shu, X.-O., Wang, T.J., Michailidou, K.,... Ziv, E. (2019). Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis. International Journal of Epidemiology, 48(3), 795-806. https://doi.org/10.1093/ije/dyy201

MLA:

Shu, Xiang, et al. "Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis." International Journal of Epidemiology 48.3 (2019): 795-806.

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