Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain
Kinfe TM, Buchfelder M, Chaudhry SR, Chakravarthy KV, Deer TR, Russo M, Georgius P, Hurlemann R, Rasheed M, Muhammad S, Yearwood TL (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 20
Journal Issue: 19
DOI: 10.3390/ijms20194737
Abstract
Chronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient. Inflammation and immunometabolism play roles in the pathophysiology of chronic pain disorders. Electrical neuromodulation approaches have shown a meaningful success in otherwise drug-resistant chronic pain conditions, including failed back surgery, neuropathic pain, and migraine. A literature review (PubMed, MEDLINE/OVID, SCOPUS, and manual searches of the bibliographies of known primary and review articles) was performed using the following search terms: chronic pain disorders, systemic inflammation, immunometabolism, prediction, biomarkers, metabolic disorders, and neuromodulation for chronic pain. Experimental studies indicate a relationship between the development and maintenance of chronic pain conditions and a deteriorated immunometabolic state mediated by circulating cytokines, chemokines, and cellular components. A few uncontrolled in-human studies found increased levels of pro-inflammatory cytokines known to drive metabolic disorders in chronic pain patients undergoing neurostimulation therapies. In this narrative review, we summarize the current knowledge and possible relationships of available neurostimulation therapies for chronic pain with mediators of central and peripheral neuroinflammation and immunometabolism on a molecular level. However, to address the needs for predictive factors and biomarkers, large-scale databank driven clinical trials are needed to determine the clinical value of molecular profiling.
Authors with CRIS profile
Thomas Mehari Kinfe
Professur für Neurochirurgie mit dem Schwerpunkt Funktionelle Stereotaktische Neurochirurgie
Michael Buchfelder
Lehrstuhl für Neurochirurgie
Involved external institutions
Shifa Tameer-e-Millat University
Pakistan (PK)
University of California, San Diego
United States (USA) (US)
The Spine & Nerve Centers
United States (USA) (US)
Hunter Integrated Pain Service (HIPS)
Australia (AU)
Nambour Selangor Private Hospital
Australia (AU)
Universitätsklinikum Bonn
Germany (DE)
St. Elisabeth Gruppe GmbH - Katholische Kliniken Rhein-Ruhr
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Neuromodulation Specialists
United States (USA) (US)
Pakistan (PK)
University of California, San Diego
United States (USA) (US)
The Spine & Nerve Centers
United States (USA) (US)
Hunter Integrated Pain Service (HIPS)
Australia (AU)
Nambour Selangor Private Hospital
Australia (AU)
Universitätsklinikum Bonn
Germany (DE)
St. Elisabeth Gruppe GmbH - Katholische Kliniken Rhein-Ruhr
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Neuromodulation Specialists
United States (USA) (US)
How to cite
APA:
Kinfe, T.M., Buchfelder, M., Chaudhry, S.R., Chakravarthy, K.V., Deer, T.R., Russo, M.,... Yearwood, T.L. (2019). Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain. International Journal of Molecular Sciences, 20(19). https://doi.org/10.3390/ijms20194737
MLA:
Kinfe, Thomas Mehari, et al. "Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain." International Journal of Molecular Sciences 20.19 (2019).
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