Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma

Erdmann M, Sigler D, Uslu U, Göhl J, Grützmann R, Schuler G, Schellerer V (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Anticancer Research International Institute of Anticancer Research (IIAR)

Book Volume: 38

Pages Range: 6571-6577

Journal Issue: 11

DOI: 10.21873/anticanres.13024

Abstract

BACKGROUND: Sentinel lymph node status is a strong prognostic factor in melanoma. However, up to 21% of sentinel lymph node-negative patients develop locoregional and distant metastases during follow-up. AIM: To analyze risk factors for locoregional and distant metastasis in patients with sentinel lymph node-negative melanoma. PATIENTS AND METHODS: A total of 545 patients underwent sentinel lymph node biopsy (SNB) between 2005 and 2013 at our hospital. Data for 449 patients with a negative SNB were analyzed regarding risk factors and development of metastases. Follow-up was performed until 2016. RESULTS: A total of 72 SNB-negative patients developed metastases, including 25 (34.7%) distant and 47 (63.3%) locoregional metastases. Locoregional metastases occurred earlier compared to distant metastases (with a mean of 24.2 and 23.5 months for regional lymph node and cutaneous metastases, respectively, vs. 31.4 months for distant metastases). Patients with metastases despite negative SNB had a greater tumor thickness (p=0.001), a higher rate of nodular melanoma (p=0.001), ulceration (p<0.001), and were older (p=0.05) compared to SNB-negative patients without subsequent metastases. Out of SNB-negative patients, 16% developed metastases. CONCLUSION: Close clinical follow-up including sonography of the draining lymph node region is mandatory for melanoma patients regardless of SNB status.

Authors with CRIS profile

Dominic Sigler Department of Surgery Ugur Uslu Department of Dermatology Jonas Göhl Professur für Chirurgie Robert Grützmann Department of Surgery Gerold Schuler Lehrstuhl für Haut- und Geschlechtskrankheiten Vera Schellerer Department of Surgery

How to cite

APA:

Erdmann, M., Sigler, D., Uslu, U., Göhl, J., Grützmann, R., Schuler, G., & Schellerer, V. (2018). Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma. Anticancer Research, 38(11), 6571-6577. https://doi.org/10.21873/anticanres.13024

MLA:

Erdmann, Michael, et al. "Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma." Anticancer Research 38.11 (2018): 6571-6577.

BibTeX: Download