Mattauch S, Sachs M, Behrens J (2010)
Publication Type: Journal article
Publication year: 2010
Book Volume: 316
Pages Range: 2883-2892
Journal Issue: 17
DOI: 10.1016/j.yexcr.2010.06.022
Liprin-α1 to liprin-α4 constitute a family of cytoplasmic proteins, which have been found in various multiprotein complexes. For liprin-α1 roles in synapse formation and cell spreading were described but other liprin family members are not well characterized. We show here that liprin-α4 is upregulated in human clear cell renal cell carcinomas (RCC) as compared to normal kidney tissue. Liprin-α4 expression is downregulated by the von Hippel-Lindau tumor suppressor (VHL) and upregulated by hypoxia in RCC cell lines. The liprin-α4 gene promoter is directly activated by binding of the hypoxia-inducible factor 1α (HIF-1α) to HRE consensus binding sites as shown by reporter assays and chromatin immunoprecipitations. RNAi mediated knockdown of liprin-α4 leads to reduced E-cadherin and Β-catenin levels at cell junctions and to dissociation of epithelial cell contacts. Our data describe for the first time liprin-α4 as a hypoxia-induced gene potentially involved in cell-cell adhesion. © 2010 Elsevier Inc.
APA:
Mattauch, S., Sachs, M., & Behrens, J. (2010). Liprin-α4 is a new hypoxia-inducible target gene required for maintenance of cell-cell contacts. Experimental Cell Research, 316(17), 2883-2892. https://doi.org/10.1016/j.yexcr.2010.06.022
MLA:
Mattauch, Sandra, Martin Sachs, and Jürgen Behrens. "Liprin-α4 is a new hypoxia-inducible target gene required for maintenance of cell-cell contacts." Experimental Cell Research 316.17 (2010): 2883-2892.
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