Mierke C (2018)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2018
Edited Volumes: Physics of Cancer
Series: Biophysical Society series
Book Volume: 1
DOI: 10.1088/978-0-7503-1753-5ch7
Chapter 7 introduces the structure and function of actin as the most abundant protein in cells and tissues from a biophysical point of view. The interaction of actin with actin-binding proteins such as actin regulatory proteins determines the role of actin and the actin filament network in distinct cellular structures such as lamellipodia, filopodia, invadopodia, the cortex and cell-cell adhesive interactions. The interaction of actin and myosin provides the cellular contractility, which is an important feature for the regulation of cancer cell migration and invasion. Moreover, the actomyosin interaction impacts the mechanical phenotype of the cells. In addition to the actomyosin interaction, other actin crosslinking molecules regulate cellular motility through the formation of distinct protrusive structures. In order to reveal the dynamic restructuring of F-actin in living cells, some live-cell imaging approaches are presented and compared to the established F-actin staining approaches for fixed and hence dead cells.
APA:
Mierke, C. (2018). Role of the actin cytoskeleton during matrix invasion. In Physics of Cancer..
MLA:
Mierke, Claudia. "Role of the actin cytoskeleton during matrix invasion." Physics of Cancer. 2018.
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