Konnerth CG, Peukert W, Braig V, Lee G (2019)
Publication Language: English
Publication Type: Journal article
Publication year: 2019
Publisher: Elsevier B.V.
Book Volume: 554
Pages Range: 54-60
Journal Issue: 554
URI: https://www.journals.elsevier.com/international-journal-of-pharmaceutics
DOI: 10.1016/j.ijpharm.2018.09.069
This is a case study of the use of rapidly-dissolving naproxen crystalline nanoparticles to prepare compressed tablets. The dissolution rates of different formulations were determined: the crystalline pure-drug nanodispersion, a pure-drug microsuspension, a granule prepared by spray drying the nanodispersion with mannitol, and a tablet prepared by compressing the granule with a bulking agent and a disintegrant. The goal was to determine the influence of each of the process steps on the rapid dissolution of the nanodispersion. A procedure was developed to allow sampling during the first 120 s of dissolution. Dissolution of the nanodispersion was completed after 60 s under both sink and non-sink conditions. Spray drying with mannitol delayed dissolution slightly under both sink and non-sink conditions. Under sink conditions a microsuspension (volume median size 11 µm) showed similar rapid dissolution to the nanodispersion. We propose this to be a result of rapid shrinkage of the microparticles on dissolution under sink conditions. This nullifies any effects of specific surface on dissolution rate. Under non-sink conditions the microparticles retain their lower specific surface for a longer time during dissolution and dissolve therefore more slowly. When compressed into tablets, the dissolution rates of nanoparticles or microparticles were determined primarily by the tablet disintegration time; the influence of sink or non-sink conditions was only observable after disintegration.
APA:
Konnerth, C.-G., Peukert, W., Braig, V., & Lee, G. (2019). Enhanced dissolution of naproxen from pure-drug, crystalline nanoparticles: A case study formulated into spray-dried granules and compressed tablets. International Journal of Pharmaceutics, 554(554), 54-60. https://doi.org/10.1016/j.ijpharm.2018.09.069
MLA:
Konnerth, Christoph-Günther, et al. "Enhanced dissolution of naproxen from pure-drug, crystalline nanoparticles: A case study formulated into spray-dried granules and compressed tablets." International Journal of Pharmaceutics 554.554 (2019): 54-60.
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