Lepko T, Pusch M, Mueller T, Schulte D, Ehses J, Kiebler M, Hasler J, Huttner H, Vandenbroucke RE, Vandendriessche C, Modic M, Martin-Villalba A, Zhao S, Llorens-Bobadilla E, Schneider A, Fischer A, Breunig CT, Stricker SH, Goetz M, Ninkovic J (2019)
Publication Type: Journal article
Publication year: 2019
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.
APA:
Lepko, T., Pusch, M., Mueller, T., Schulte, D., Ehses, J., Kiebler, M.,... Ninkovic, J. (2019). Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. EMBO Journal. https://doi.org/10.15252/embj.2018100481
MLA:
Lepko, Tjasa, et al. "Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain." EMBO Journal (2019).
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