Radulovic K, Ayata CK, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, De Aguero MG, Broz P, Weigmann B, Niess JH (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 203
Pages Range: 544-556
Journal Issue: 2
The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4(+) T cells led to decreased survival.
APA:
Radulovic, K., Ayata, C.K., Mak'Anyengo, R., Lechner, K., Wuggenig, P., Kaya, B.,... Niess, J.H. (2019). NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. Journal of Immunology, 203(2), 544-556. https://doi.org/10.4049/jimmunol.1800938
MLA:
Radulovic, Katarina, et al. "NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death." Journal of Immunology 203.2 (2019): 544-556.
BibTeX: Download