Magnetically responsive composites: Electron beam assisted magnetic nanoparticle arrest in gelatin hydrogels for bioactuation

Deuflhard M, Eberbeck D, Hietschold P, Wilharm N, Mühlberger M, Friedrich RP, Alexiou C, Mayr SG (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Physical Chemistry Chemical Physics Royal Society of Chemistry

Book Volume: 21

Pages Range: 14654-14662

Journal Issue: 27

DOI: 10.1039/c9cp02910a

Abstract

As emerging responsive materials, ferrogels have become highly attractive for biomedical and technical applications in terms of soft actuation, tissue engineering or controlled drug release. In the present study, bioderived ferrogels were fabricated and successfully deformed within moderate, heterogeneous magnetic fields. Synthesis was realized by arresting iron oxide nanoparticles in porcine gelatin by introduction of covalent crosslinks via treatment with energetic electrons for mesh refinement. This approach also allows for tuning thermal and mechanical stability of the gelatin matrix. Operating the bioferrogel in compression, magnetic forces on the nanoparticles are counterbalanced by the stiffness of the hydrogel matrix that is governed by a shift in thermodynamic equilibrium of swelling, as derived in the framework of osmosis. As gelatin and iron oxide nanoparticles are established as biocompatible constituents, these findings promise potential for in vivo use as contactless mechanical transducers.

Authors with CRIS profile

Marina Mühlberger Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Leibniz-Institute für Oberflächenmodifizierung e. V. (IOM) / Leibniz Institute of Surface Modification DE Germany (DE) Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE)

How to cite

APA:

Deuflhard, M., Eberbeck, D., Hietschold, P., Wilharm, N., Mühlberger, M., Friedrich, R.P.,... Mayr, S.G. (2019). Magnetically responsive composites: Electron beam assisted magnetic nanoparticle arrest in gelatin hydrogels for bioactuation. Physical Chemistry Chemical Physics, 21(27), 14654-14662. https://doi.org/10.1039/c9cp02910a

MLA:

Deuflhard, Marie, et al. "Magnetically responsive composites: Electron beam assisted magnetic nanoparticle arrest in gelatin hydrogels for bioactuation." Physical Chemistry Chemical Physics 21.27 (2019): 14654-14662.

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