Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel F, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A (2019)
Publication Type: Journal article
Publication year: 2019
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nyas.14094
The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.
APA:
Morgan, R.K., Anderson, G.R., Araç, D., Aust, G., Balenga, N., Boucard, A.,... Mogha, A. (2019). The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors. Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.14094
MLA:
Morgan, Rory K., et al. "The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors." Annals of the New York Academy of Sciences (2019).
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