Müller-Deile J, Schenk H, Schroder P, Schulze K, Bolaños-Palmieri P, Siegerist F, Endlich N, Haller H, Schiffer M (2019)
Publication Type: Journal article
Publication year: 2019
DOI: 10.1016/j.kint.2019.02.013
Proteinuria can be induced by impairment of any component of the glomerular filtration barrier. To determine the role of circulating permeability factors on glomerular damage, we developed a parabiosis-based zebrafish model to generate a common circulation between zebrafish larvae. A morpholino-mediated knockdown of a podocyte specific gene (nephronectin) was induced in one zebrafish larva which was then fused to an un-manipulated fish. Notably, proteinuria and glomerular damage were present in the manipulated fish and in the parabiotically-fused partner. Thus, circulating permeability factors may be induced by proteinuria even when an induced podocyte gene dysregulation is the initiating cause.
APA:
Müller-Deile, J., Schenk, H., Schroder, P., Schulze, K., Bolaños-Palmieri, P., Siegerist, F.,... Schiffer, M. (2019). Circulating factors cause proteinuria in parabiotic zebrafish. Kidney International. https://doi.org/10.1016/j.kint.2019.02.013
MLA:
Müller-Deile, J., et al. "Circulating factors cause proteinuria in parabiotic zebrafish." Kidney International (2019).
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