Meissner R, Bertol L, Ur Rehman MA, Loureiro Dos Santos LA, Boccaccini AR (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 45
Pages Range: 7090-7094
Journal Issue: 6
DOI: 10.1016/j.ceramint.2018.12.212
We investigated the suitability of 3D printed calcium phosphate scaffolds as drug carriers. The 3D powder printing process utilized a-tricalcium phosphate (alpha-TCP) as a solid phase and deionized water with 2.5% disodium hydrogen phosphate as a setting accelerator. The antibiotic gentamicin sulfate was incorporated by mixing it into alpha-TCP powder before printing. Two different concentrations of gentamicin (3 wt%, 7 wt%) were used to study the correlation between drug release kinetics and gentamicin content in the scaffolds. The scaffolds were hardened at 100% humidity. The synthesized scaffolds were characterized in terms of morphology, composition, mechanical strength, in vitro bioactivity and drug release kinetics. X-ray diffraction (XRD) analysis revealed that the alpha-TCP converted into calcium deficient hydroxyapatite (CDHA) during the printing process. Scanning electron microscopy (SEM) showed the typical needle-like structure of CDHA. Gentamicin release was investigated for a period of two weeks with an initial burst release. The produced scaffolds formed calcium enriched apatite crystals on their surface after three days of incubation in simulated body fluid.
APA:
Meissner, R., Bertol, L., Ur Rehman, M.A., Loureiro Dos Santos, L.A., & Boccaccini, A.R. (2019). Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability. Ceramics International, 45(6), 7090-7094. https://doi.org/10.1016/j.ceramint.2018.12.212
MLA:
Meissner, Ruth, et al. "Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability." Ceramics International 45.6 (2019): 7090-7094.
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