Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women

Kadalayil L, Khan S, Nevanlinna H, Fasching P, Couch FJ, Hopper JL, Liu J, Maishman T, Durcan L, Gerty S, Blomqvist C, Rack B, Janni W, Collins A, Eccles D, Tapper W (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Nature Communications Nature Publishing Group: Nature Communications

Book Volume: 8

Journal Issue: 1

DOI: 10.1038/s41467-017-01775-y

Abstract

To identify genetic variants associated with breast cancer prognosis we conduct a meta-analysis of overall survival (OS) and disease-free survival (DFS) in 6042 patients from four cohorts. In young women, breast cancer is characterized by a higher incidence of adverse pathological features, unique gene expression profiles and worse survival, which may relate to germline variation. To explore this hypothesis, we also perform survival analysis in 2315 patients aged ≤ 40 years at diagnosis. Here, we identify two SNPs associated with early-onset DFS, rs715212 (P meta = 3.54 × 10-5) and rs10963755 (P meta = 3.91 × 10-4) in ADAMTSL1. The effect of these SNPs is independent of classical prognostic factors and there is no heterogeneity between cohorts. Most importantly, the association with rs715212 is noteworthy (FPRP <0.2) and approaches genome-wide significance in multivariable analysis (P multivariable = 5.37 × 10-8). Expression quantitative trait analysis provides tentative evidence that rs715212 may influence AREG expression (P eQTL = 0.035), although further functional studies are needed to confirm this association and determine a mechanism.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

University of Southampton GB United Kingdom (GB) Helsingin yliopisto / University of Helsinki FI Finland (FI) Mayo Clinic US United States (USA) (US) The University of Melbourne AU Australia (AU) Genome Institute of Singapore SG Singapore (SG) Universität Ulm DE Germany (DE)

How to cite

APA:

Kadalayil, L., Khan, S., Nevanlinna, H., Fasching, P., Couch, F.J., Hopper, J.L.,... Tapper, W. (2017). Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women. Nature Communications, 8(1). https://doi.org/10.1038/s41467-017-01775-y

MLA:

Kadalayil, Latha, et al. "Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women." Nature Communications 8.1 (2017).

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