Eirich A, Biermann T, Müller CP, Kornhuber J, Benyamin B, Hulse GK, Wildenauer DB, Schwab S (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 29
Pages Range: 18-25
Journal Issue: 1
DOI: 10.1097/YPG.0000000000000208
Objectives Susceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well as environmental factors, are likely to contribute to its etiology. Not all individuals who have ever tried heroin at some stage during their lifetime become dependent on heroin. It has been suggested that genetic factors might be more important in the transition stage to heroin dependence rather than in environmental exposures and experimenting with heroin. As the features of substance dependence and memory formation have been found to be strikingly similar, we have focused on a key enzyme involved in long-term potentiation and synaptic plasticity, namely the calcium-dependent/calmodulin-dependent protein kinase IIa (CAMKIIa). We hypothesized, that CamK2A genetic variation may play a role in the transition from occasional to regular heroin use.
APA:
Eirich, A., Biermann, T., Müller, C.P., Kornhuber, J., Benyamin, B., Hulse, G.K.,... Schwab, S. (2019). Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals. Psychiatric Genetics, 29(1), 18-25. https://doi.org/10.1097/YPG.0000000000000208
MLA:
Eirich, Antonia, et al. "Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals." Psychiatric Genetics 29.1 (2019): 18-25.
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