Kuhlen M, Bader P, Sauer M, Albert MH, Gruhn B, Gungor T, Kropshofer G, Lang P, Lawitschka A, Metzler M, Pentek F, Rossig C, Schlegel PG, Schrappe M, Schrum J, Schulz A, Schwinger W, Von Stackelberg A, Strahm B, Suttorp M, Teichert-Von Luettichau I, Woessmann W, Borkhardt A, Meisel R, Poetschger U, Glogova E, Peters C (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 183
Pages Range: 104-109
Journal Issue: 1
DOI: 10.1111/bjh.15511
Osteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin-Frankfurt-Münster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 10·3 years (range 0·5-26). Cumulative incidence of symptomatic ON (sON) was 9% at 5 years (standard deviation 1%), median time from HSCT to diagnosis of sON was 12·4 months (range 1-126). Multivariate analysis identified age at HSCT [10-15 years vs. <10 years: hazard ratio (HR) 3·73, P = 0·009; >15 years vs. <10 years: HR 5·46, P = 0·001], diagnosis of sON prior to HSCT and chronic graft-versus-host disease (yes versus no: HR 2·696, P = 0·015) as significant independent risk factors for the development of sON.
APA:
Kuhlen, M., Bader, P., Sauer, M., Albert, M.H., Gruhn, B., Gungor, T.,... Peters, C. (2018). Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial. British Journal of Haematology, 183(1), 104-109. https://doi.org/10.1111/bjh.15511
MLA:
Kuhlen, Michaela, et al. "Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial." British Journal of Haematology 183.1 (2018): 104-109.
BibTeX: Download