Influence of symptom typicality for predicting MACE in patients without obstructive coronary artery disease: From the CONFIRM Registry (Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)

Lee JH, Han D, Hartaigh BO, Gransar H, Lu Y, Rizvi A, Park MW, Roudsari HM, Stuijfzand WJ, Berman DS, Callister TQ, Delago A, Hadamitzky M, Hausleiter J, Al-Mallah MH, Budoff MJ, Kaufmann PA, Raff G, Chinnaiyan K, Cademartiri F, Maffei E, Villines TC, Kim YJ, Leipsic J, Feuchtner G, Pontone G, Andreini D, Marques H, Rubinshtein R, Achenbach S, Shaw LJ, Chang HJ, Bax J, Chow B, Cury RC, Gomez M, Jones EC, Lin FY, Min JK, Pena JM (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 41

Pages Range: 586-593

Journal Issue: 5

DOI: 10.1002/clc.22940

Abstract

Our objective was to assess the prognostic value of symptom typicality in patients without obstructive coronary artery disease (CAD), determined by coronary computed tomographic angiography (CCTA). We identified 4215 patients without prior history of CAD and without obstructive CAD (<50% CCTA stenosis). CAD severity was categorized as nonobstructive (1%-49%) and none (0%). Based upon the Diamond-Forrester criteria for angina pectoris, symptom typicality was classified as asymptomatic, nonanginal, atypical, and typical. Multivariable Cox proportional hazards models were used to assess the risk of major adverse cardiac events (MACE), comprising all-cause mortality, myocardial infarction, unstable angina, and late revascularization, according to symptom typicality. Mean patient age was 57.0 ±12.0 years (54.9% male). During a median follow-up of 5.3 years (interquartile range, 4.6-5.9 years), MACE were reported in 312 (7.4%) patients. Among patients with nonobstructive CAD, there was an association between symptom typicality and MACE (P for interaction = 0.05), driven by increased risk of MACE among those with typical angina and nonobstructive CAD (hazard ratio: 1.62, 95% confidence interval: 1.06-2.48, P = 0.03). No consistent relationship was found between symptom typicality and MACE among patients without any CAD (hazard ratio: 0.73, 95% confidence interval: 0.34-1.57, P = 0.08). In the CONFIRM registry, patients who presented with concomitant typical angina and nonobstructive CAD had a higher rate of MACE than did asymptomatic patients with nonobstructive CAD. However, the presence of typical angina did not appear to portend worse prognosis in patients with no CAD.

Authors with CRIS profile

Involved external institutions

Medizinische Universität Innsbruck Austria (AT) Università degli studi di Milano Italy (IT) Deutsches Herzzentrum München Germany (DE) New York Presbyterian Hospital United States (USA) (US) Cedars-Sinai Medical Center United States (USA) (US) Beaumont Health System United States (USA) (US) Walter Reed Army Medical Center (WRAMC) United States (USA) (US) Seoul National University (SNU) / 서울대학교 Korea, Republic of (KR) Tennessee Heart & Vascular United States (USA) (US) University of British Columbia Canada (CA) SDN Istituto di Ricerca Diagnostica e Nucleare Italy (IT) King Abdullah International Medical Research Center (KAIMRC) Saudi Arabia (SA) Technion - Israel Institute of Technology Israel (IL) Hospital da Luz Portugal (PT) Ludwig-Maximilians-Universität (LMU) Germany (DE) Harbor–UCLA Medical Center United States (USA) (US) Universitätsklinik Balgrist Switzerland (CH) Capitol Cardiology Associates United States (USA) (US) Emory University United States (USA) (US) Leiden University Netherlands (NL) Myongji Hospital Korea, Republic of (KR) University of Ottawa Canada (CA)

How to cite

APA:

Lee, J.H., Han, D., Hartaigh, B.O., Gransar, H., Lu, Y., Rizvi, A.,... Pena, J.M. (2018). Influence of symptom typicality for predicting MACE in patients without obstructive coronary artery disease: From the CONFIRM Registry (Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry). Clinical Cardiology, 41(5), 586-593. https://doi.org/10.1002/clc.22940

MLA:

Lee, Ji Hyun, et al. "Influence of symptom typicality for predicting MACE in patients without obstructive coronary artery disease: From the CONFIRM Registry (Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)." Clinical Cardiology 41.5 (2018): 586-593.

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