Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes
Lin YT, Froemberg D, Huang W, Delivani P, Chacon M, Tolic IM, Juelicher F, Zaburdaev V (2015)
Publication Status: Published
Publication Type: Journal article
Publication year: 2015
Journal
Publisher: AMER PHYSICAL SOC
Book Volume: 115
Journal Issue: 20
DOI: 10.1103/PhysRevLett.115.208102
Abstract
During recombination, the DNA of parents exchange their genetic information to give rise to a genetically unique offspring. For recombination to occur, homologous chromosomes need to find each other and align with high precision. Fission yeast solves this problem by folding chromosomes in loops and pulling them through the viscous nucleoplasm. We propose a theory of pulled polymer loops to quantify the effect of drag forces on the alignment of chromosomes. We introduce an external force field to the concept of a Brownian bridge and thus solve for the statistics of loop configurations in space.
Authors with CRIS profile
Additional Organisation(s)
Involved external institutions
Max-Planck-Institut für Physik komplexer Systeme (MPI PKS) / Max Planck Institute for the Physics of Complex Systems
Germany (DE)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Germany (DE)
Germany (DE)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Germany (DE)
How to cite
APA:
Lin, Y.T., Froemberg, D., Huang, W., Delivani, P., Chacon, M., Tolic, I.M.,... Zaburdaev, V. (2015). Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes. Physical Review Letters, 115(20). https://doi.org/10.1103/PhysRevLett.115.208102
MLA:
Lin, Yen Ting, et al. "Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes." Physical Review Letters 115.20 (2015).
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