The human meibomian gland epithelial cell line as a model to study meibomian gland dysfunction
Hampel U, Garreis F (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 163
Pages Range: 46-52
DOI: 10.1016/j.exer.2017.03.011
Abstract
The meibomian gland dysfunction (MGD) is the leading cause of dry eye disease (DED) throughout the world. The investigation of MGD lacks suitable in vivo and in vitro models. In 2010 a human meibomian gland epithelial cell line (HMGEC) was established, so far the only available meibomian gland cell line. The characterization of HMGEC is of major importance to clarify its suitability for studying the meibomian gland (patho)physiology in vitro. The current culture protocol and new concepts of HMGEC culture will be compared. Hormones are believed to be a key factor in meibomian gland dysfunction thus HMGEC responsiveness to hormone stimulation is crucial to elucidate the hormonal influence on the meibomian gland. This review will summarize current findings about HMGEC and discuss its role in the meibomian gland dysfunction research.
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Germany (DE)How to cite
APA:
Hampel, U., & Garreis, F. (2017). The human meibomian gland epithelial cell line as a model to study meibomian gland dysfunction. Experimental Eye Research, 163, 46-52. https://doi.org/10.1016/j.exer.2017.03.011
MLA:
Hampel, Ulrike, and Fabian Garreis. "The human meibomian gland epithelial cell line as a model to study meibomian gland dysfunction." Experimental Eye Research 163 (2017): 46-52.
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