Management of Chronic Hepatic Itch

Düll M, Kremer A (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Dermatologic Clinics WB Saunders

Book Volume: 36

Pages Range: 293-300

Journal Issue: 3

DOI: 10.1016/j.det.2018.02.008

Abstract

Hepatic itch remains among the most agonizing symptoms for affected patients and a major clinical challenge for physicians. Pruritus may occur in almost all liver diseases, particularly those with cholestatic features. Hepatic itch arises irrespective of the severity of the underlying liver disease or extent of cholestasis. Antihistamines are ineffective in hepatic itch. Therapeutic recommendations consist of a guideline-based stepwise approach, starting with the anion exchange resin cholestyramine, followed by rifampicin, naltrexone, and sertraline. Bezafibrate and ileal bile acid transporter inhibitors are promising future treatment options. Experimental and invasive procedures should be reserved for refractory pruritus.

Authors with CRIS profile

Miriam Düll Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Andreas Kremer Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

How to cite

APA:

Düll, M., & Kremer, A. (2018). Management of Chronic Hepatic Itch. Dermatologic Clinics, 36(3), 293-300. https://doi.org/10.1016/j.det.2018.02.008

MLA:

Düll, Miriam, and Andreas Kremer. "Management of Chronic Hepatic Itch." Dermatologic Clinics 36.3 (2018): 293-300.

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