Sustar M, Holder GE, Kremers J, Barnes CS, Lei B, Khan NW, Robson AG (2018)
Publication Type: Journal article, Original article
Publication year: 2018
Book Volume: 136
Pages Range: 199-206
Journal Issue: 3
DOI: 10.1007/s10633-018-9645-y
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave. The Off d-wave is a positive component evoked by stimulus offset. Common diagnoses that may benefit from additional photopic On-Off ERG testing include retinal dystrophies and retinal disorders that cause dysfunction at a level that is post-phototransduction or post-receptoral. On-Off ERGs assess the relative involvement of On- and Off-systems and may be of use in the diagnosis of disorders such as complete and incomplete congenital stationary night blindness (complete and incomplete CSNB), melanoma-associated retinopathy, and some forms of autoimmune retinopathy. The photopic On-Off ERGs may also be useful in X-linked retinoschisis, Batten disease, Duchenne muscular dystrophy, spinocerebellar degeneration, quinine toxicity, and other retinal disorders.
APA:
Sustar, M., Holder, G.E., Kremers, J., Barnes, C.S., Lei, B., Khan, N.W., & Robson, A.G. (2018). ISCEV extended protocol for the photopic On-Off ERG. Documenta Ophthalmologica, 136(3), 199-206. https://doi.org/10.1007/s10633-018-9645-y
MLA:
Sustar, Maja, et al. "ISCEV extended protocol for the photopic On-Off ERG." Documenta Ophthalmologica 136.3 (2018): 199-206.
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