Model-Based Phenotypic Signatures Governing the Dynamics of the Stem and Semi-differentiated Cell Populations in Dysplastic Colonic Crypts

Nikolov S, Santos Rosales G, Wolkenhauer O, Vera J (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Bulletin of Mathematical Biology Springer Verlag (Germany)

Book Volume: 80

Pages Range: 360-384

Journal Issue: 2

DOI: 10.1007/s11538-017-0378-y

Abstract

Mathematical modeling of cell differentiated in colonic crypts can contribute to a better understanding of basic mechanisms underlying colonic tissue organization, but also its deregulation during carcinogenesis and tumor progression. Here, we combined bifurcation analysis to assess the effect that time delay has in the complex interplay of stem cells and semi-differentiated cells at the niche of colonic crypts, and systematic model perturbation and simulation to find model-based phenotypes linked to cancer progression. The models suggest that stem cell and semi-differentiated cell population dynamics in colonic crypts can display chaotic behavior. In addition, we found that clinical profiling of colorectal cancer correlates with the in silico phenotypes proposed by the mathematical model. Further, potential therapeutic targets for chemotherapy resistant phenotypes are proposed, which in any case will require experimental validation.

Authors with CRIS profile

Guido Santos Rosales Department of Dermatology Julio Vera González Professur für Tumorimmunologie (Schwerpunkt Systembiologie)

Involved external institutions

Universität Rostock DE Germany (DE)

How to cite

APA:

Nikolov, S., Santos Rosales, G., Wolkenhauer, O., & Vera, J. (2018). Model-Based Phenotypic Signatures Governing the Dynamics of the Stem and Semi-differentiated Cell Populations in Dysplastic Colonic Crypts. Bulletin of Mathematical Biology, 80(2), 360-384. https://doi.org/10.1007/s11538-017-0378-y

MLA:

Nikolov, Svetoslav, et al. "Model-Based Phenotypic Signatures Governing the Dynamics of the Stem and Semi-differentiated Cell Populations in Dysplastic Colonic Crypts." Bulletin of Mathematical Biology 80.2 (2018): 360-384.

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