Checkpoint inhibitors and radiation treatment in Hodgkin's lymphoma : New study concepts of the German Hodgkin Study Group
Baues C, Semrau R, Gaipl U, Broeckelmann PJ, Rosenbrock J, Engert A, Marnitz S (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 193
Pages Range: 95-99
Journal Issue: 2
DOI: 10.1007/s00066-016-1050-4
Abstract
BACKGROUND: Patients with classical Hodgkin's lymphoma (cHL) have a good prognosis even in advanced stages. However, combined chemo- and radiotherapy, as the standard of care, is also associated with treatment-related toxicities such as organ damage, secondary neoplasias, infertility, or fatigue and long-term fatigue. Many patients suffer from this burden although their cHL was cured. Therefore, the efficacy of immune checkpoint inhibitors like anti-PD1/PD-L1 antibodies in the treatment of solid cancers and also in HL offers new options. A remarkable and durable response rate with a favorable toxicity profile was observed in heavily pretreated cHL patients. METHODS: Planning to perform prospective randomized clinical trials in the content of radio-immune treatment in patients with Hodgkin's lymphoma (HL), we transferred the results of preliminary clinical studies and basic research in clinical relevant study concepts. RESULTS: Based on these promising early phase trial data, the German Hodgkin Study Group (GHSG) will investigate innovative treatment regimens in upcoming phase II trials. CONCLUSION: The therapeutic efficacy and potential synergies of anti-PD1 antibodies in combination with chemo- or radiotherapy will be investigated in various settings of HL.
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Germany (DE)How to cite
APA:
Baues, C., Semrau, R., Gaipl, U., Broeckelmann, P.J., Rosenbrock, J., Engert, A., & Marnitz, S. (2017). Checkpoint inhibitors and radiation treatment in Hodgkin's lymphoma : New study concepts of the German Hodgkin Study Group. Strahlentherapie und Onkologie, 193(2), 95-99. https://doi.org/10.1007/s00066-016-1050-4
MLA:
Baues, C., et al. "Checkpoint inhibitors and radiation treatment in Hodgkin's lymphoma : New study concepts of the German Hodgkin Study Group." Strahlentherapie und Onkologie 193.2 (2017): 95-99.
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