Pfeiffer H, Herbst L, Schwarze B, Eckstein R, Weisbach VG (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 95
Journal Issue: 44
DOI: 10.1097/MD.0000000000005343
RATIONALE: Oral anticoagulants and painkillers, some with an additional effect on the coagulation system, are widely used and are therefore prone to abuse and (intentional) overdose. We report the case of a patient with a massive mixed anticoagulant intoxication. PATIENT CONCERNS: The patient had ingested 1960 mg rivaroxaban, 31.5 mg phenprocoumon, 1425 mg diclofenac, and 21,000 mg metamizole in suicidal intention. DIAGNOSES: Massive mixed anticoagulant overdose. INTERVENTIONS: The patient was closely monitored. The phenprocoumon overdose was treated by the administration of vitamin K and PCC. OUTCOMES: Despite the massive inhibition of the coagulation system, the patient did not experience bleeding apart from a slight gross hematuria. LESSONS: Despite the ingestion of a massive amount of rivaroxaban, the plasma levels were not as high as feared, due to the ceiling effect of rivaroxaban absorption. Elimination occurred according to the half-life of rivaroxaban and was not unduly prolonged by the ingested quantity.
APA:
Pfeiffer, H., Herbst, L., Schwarze, B., Eckstein, R., & Weisbach, V.G. (2016). Massive intoxication with rivaroxaban, phenprocoumon, and diclofenac: A case report. Medicine, 95(44). https://doi.org/10.1097/MD.0000000000005343
MLA:
Pfeiffer, Hella, et al. "Massive intoxication with rivaroxaban, phenprocoumon, and diclofenac: A case report." Medicine 95.44 (2016).
BibTeX: Download