Pathophysiology of Headaches

Gaul C, Meßlinger K, Holle-Lee D, Neeb L (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Deutsche Medizinische Wochenschrift Georg Thieme Verlag

Book Volume: 142

Pages Range: 402-408

Journal Issue: 6

DOI: 10.1055/s-0042-111694

Abstract

Pathophysiological concepts of primary headache diseases have been developed significantly in the last decades. Nevertheless pathophysiology of single diseases is unexplained. Migraine headache arises from activation and sensibilization of trigeminal nociceptors, essential processes are located at the meninges and the meningeal vessels. Calcitonin gene-related peptide (CGRP) seems to have essential importance concerning migraine and cluster headache. Mechanisms leading to peripheral and central sensitization are relevant in chronification of migraine and tension-type headache. As a higher-level centre the hypothalamus seems to have an essential meaning in the initiation of migraine attacks. Dysbalance between the sympathetic and parasympathetic neural system causes cranial-autonomic symptoms in some headache diseases and can be affected therapeutically.

Authors with CRIS profile

Karl Meßlinger Professur für Zelluläre und Molekulare Neurophysiologie

Involved external institutions

Migräne-Klinik Königstein DE Germany (DE) Universitätsklinikum Essen DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Gaul, C., Meßlinger, K., Holle-Lee, D., & Neeb, L. (2017). Pathophysiology of Headaches. Deutsche Medizinische Wochenschrift, 142(6), 402-408. https://doi.org/10.1055/s-0042-111694

MLA:

Gaul, Charly, et al. "Pathophysiology of Headaches." Deutsche Medizinische Wochenschrift 142.6 (2017): 402-408.

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