Blood Pressure in a Large Cohort of Children and Adolescents With Classic Adrenal Hyperplasia (CAH) Due to 21-Hydroxylase Deficiency
Bonfig W, Roehl FW, Riedl S, Dörr HG, Bettendorf M, Braemswig J, Schoenau E, Riepe F, Hauffa B, Holl RW, Mohnike K (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 29
Pages Range: 266-72
Journal Issue: 2
DOI: 10.1093/ajh/hpv087
Abstract
BACKGROUND: Data on blood pressure (BP) in children and adolescents with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency are conflicting in the literature. PATIENTS AND METHODS: BP data of n = 716 children and adolescents (aged 3-18 years) from a national CAH database were analyzed. BP data were adjusted for height and compared to contemporary national reference data. A systolic and diastolic BP above the 95th centile was defined as hypertensive. RESULTS: Overall prevalence of hypertension was 12.5%. Prevalence of hypertension was higher in younger children than in adolescents (18.5% vs. 4.9%). Until 8 years of age, fludrocortisone dose/m(2)/day correlated significantly with BP in regression analysis (P < 0.0001). BP correlated significantly with body mass index standard deviation score (BMI-SDS) (P < 0.0001), but not with hydrocortisone dose. In patients with salt-wasting CAH, BMI-SDS and BP were significantly higher compared to patients with simple virilising CAH, P < 0.01. CONCLUSION: Especially young CAH children seem to be at risk for-most likely transient-hypertension, since the prevalence of hypertension decreases with age. In children up to 8 years of age, the used fludrocortisone dose is a significant risk factor for hypertension. Therefore we recommend accurate measurement of BP and careful fludrocortisone dosing in children with CAH.
Authors with CRIS profile
Helmuth-Günther Dörr
Professur für Kinderheilkunde mit dem Schwerpunkt Kinder-Endokrinologie und Diabetologie (Stiftungsprofessur)
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Universitätsklinikum Heidelberg
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Universitätsklinikum Köln
Germany (DE)
Universitätsklinikum Essen
Germany (DE)
Universität Ulm
Germany (DE)
Germany (DE)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Universitätsklinikum Heidelberg
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Universitätsklinikum Köln
Germany (DE)
Universitätsklinikum Essen
Germany (DE)
Universität Ulm
Germany (DE)
How to cite
APA:
Bonfig, W., Roehl, F.-W., Riedl, S., Dörr, H.-G., Bettendorf, M., Braemswig, J.,... Mohnike, K. (2016). Blood Pressure in a Large Cohort of Children and Adolescents With Classic Adrenal Hyperplasia (CAH) Due to 21-Hydroxylase Deficiency. American Journal of Hypertension, 29(2), 266-72. https://doi.org/10.1093/ajh/hpv087
MLA:
Bonfig, Walter, et al. "Blood Pressure in a Large Cohort of Children and Adolescents With Classic Adrenal Hyperplasia (CAH) Due to 21-Hydroxylase Deficiency." American Journal of Hypertension 29.2 (2016): 266-72.
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