Prospective intraindividual comparison of gadoterate and gadobutrol for cervical and intracranial contrast-enhanced magnetic resonance angiography
Lang S, Weibart M, Schmidt M, Knott M, Engelhorn T, Essig M, Kloska S, Dörfler A, Hölter P (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 59
Pages Range: 1233-1239
Journal Issue: 12
DOI: 10.1007/s00234-017-1922-z
Abstract
PURPOSE: Gadobutrol (GB) is reported to provide improved relaxivity and concentration compared to gadoterate (GT). This study was designed to intraindividually compare quantitative and qualitative enhancement characteristics of GB to GT in cervicocranial magnetic resonance angiography (MRA) of patients with cerebrovascular disease (CVD). METHODS: Patients (n = 54) with CVD underwent two identical contrast-enhanced magnetic resonance angiography (CE-MRA) examinations of the cervical and intracranial vasculature in randomized order, using GB and GT in equimolar dose. Signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) were obtained by two independent neuroradiologists, blinded to the applied contrast agents. Qualitative assessment was performed using a three-point scale with a focus on M1/M2 segments. RESULTS: One thousand and twenty-six vessel segments were analyzed. GB revealed a significantly higher SNR (p = 0.032) and CNR (p = 0.031) in all vessel segments. GB featured a significantly higher SNR and CNR in thoracic (p = 0.022; p = 0.016) and cervical vessels (p = 0.03; p = 0.038), as well as in the posterior circulation (p = 0.012; p = 0.005). In blinded qualitative assessment, overall preference was given to GB (p = 0.02), showing a significant better delineation of the M1/M2 segments (p = 0.041). CONCLUSION: Compared to GT, the use of GB results in a significantly higher SNR and CNR in cervical and cerebral CE-MRA, leading to a better delineation of the intracranial vasculature. Present results underline the potential of GB for improved CE-MRA assessment of vasculature in CVD patients.
Authors with CRIS profile
Manuel Schmidt
Department of Neuroradiology
Michael Knott
Medizinische Fakultät
Tobias Martin Engelhorn
Department of Neuroradiology
Stephan Kloska
Department of Neuroradiology
Arnd Dörfler
Department of Neuroradiology
Philip Hölter
Department of Neuroradiology
Involved external institutions
Canada (CA)How to cite
APA:
Lang, S., Weibart, M., Schmidt, M., Knott, M., Engelhorn, T., Essig, M.,... Hölter, P. (2017). Prospective intraindividual comparison of gadoterate and gadobutrol for cervical and intracranial contrast-enhanced magnetic resonance angiography. Neuroradiology, 59(12), 1233-1239. https://doi.org/10.1007/s00234-017-1922-z
MLA:
Lang, Stefan, et al. "Prospective intraindividual comparison of gadoterate and gadobutrol for cervical and intracranial contrast-enhanced magnetic resonance angiography." Neuroradiology 59.12 (2017): 1233-1239.
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