Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

Lukasz A, Beneke J, Thamm K, Kielstein JT, Menne J, Mikesch JH, Schmidt BMW, Haller H, Kuempers P, David S, Schiffer M (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Mediators of Inflammation Hindawi Publishing Corporation

Book Volume: 2015

DOI: 10.1155/2015/670248

Abstract

Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels quantified in 48 adult HUS patients were predictive for a complicated clinical course, in particular for need of hemodialysis and mechanical ventilation as well as occurrence of seizures. In vitro challenge of human umbilical vein endothelial cells with patients' sera indicated an injurious mediator role of Angpt-2 opening future perspectives for mitigating endothelial activation in HUS.

Authors with CRIS profile

Mario Schiffer

Additional Organisation(s)

Lehrstuhl für Innere Medizin IV

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsklinikum Münster DE Germany (DE)

How to cite

APA:

Lukasz, A., Beneke, J., Thamm, K., Kielstein, J.T., Menne, J., Mikesch, J.-H.,... Schiffer, M. (2015). Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4. Mediators of Inflammation, 2015. https://doi.org/10.1155/2015/670248

MLA:

Lukasz, Alexander, et al. "Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4." Mediators of Inflammation 2015 (2015).

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