Weigmann B, Neurath M (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 39
Pages Range: 89-95
Journal Issue: 1
DOI: 10.1007/s00281-016-0603-z
Inflammatory bowel diseases are chronic, relapsing, immunologically mediated disorders of the gastrointestinal tract. Emerging evidence suggests a critical functional role of transcription factors and T cell-related cytokines in ulcerative colitis and Crohn's disease. Gut-residing T cells from patients with inflammatory bowel disease produce high amounts of IL-9. Experimental models of colitis highlighted that IL-9-producing T cells critically interfered with an intact barrier function of the intestinal epithelium by impacting cellular proliferation and tight junction molecules. The blockade of IL-9 was suited to significantly ameliorate the disease activity and severity in experimental models of inflammatory bowel disease thereby suggesting that targeting IL-9 might function as a novel targeted approach for therapy.
APA:
Weigmann, B., & Neurath, M. (2017). Th9 cells in inflammatory bowel diseases. Seminars in Immunopathology, 39(1), 89-95. https://doi.org/10.1007/s00281-016-0603-z
MLA:
Weigmann, Benno, and Markus Neurath. "Th9 cells in inflammatory bowel diseases." Seminars in Immunopathology 39.1 (2017): 89-95.
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