Seidel K, Balakrishnan A, Alexiou C, Janko C, Komoll RM, Wang LL, Kirschning A, Ott M (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 23
Pages Range: 12326-12337
Journal Issue: 50
Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour-selective drug delivery and release. It combines chemo- with thermal therapy. The linker-modified toxin was prepared by a combination of biotechnology and semisynthesis. Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model. Biocompatibility studies for these magnetic-nanoparticle/ansamitocin conjugates complement this work.
APA:
Seidel, K., Balakrishnan, A., Alexiou, C., Janko, C., Komoll, R.-M., Wang, L.-L.,... Ott, M. (2017). Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo. Chemistry - A European Journal, 23(50), 12326-12337. https://doi.org/10.1002/chem.201701491
MLA:
Seidel, Katja, et al. "Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo." Chemistry - A European Journal 23.50 (2017): 12326-12337.
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