Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial

Heratizadeh A, Werfel T, Wollenberg A, Abraham S, Plank-Habibi S, Schnopp C, Sticherling M, Apfelbacher C, Biedermann T, Breuer K, Fell I, Foelster-Holst R, Heine G, Grimm J, Hennighausen L, Kugler C, Reese I, Ring J, Schakel K, Schmitt J, Seikowski K, Von Stebut E, Wagner N, Wassmann-Otto A, Wienke-Graul U, Weisshaar E, Worm M, Gieler U, Kupfer J (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 140

Pages Range: 845-853.e3

Journal Issue: 3

DOI: 10.1016/j.jaci.2017.01.029

Abstract

BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing skin disease prevalent in 1% to 3% of adults in Western industrialized countries. OBJECTIVE: We sought to investigate the effectiveness of educational training in an outpatient setting on coping with the disease, quality of life, symptoms, and severity in adults with AD. METHODS: In this German prospective, randomized controlled multicenter study, adult patients with moderate-to-severe AD were educated by referring to a comprehensive 12-hour training manual consented by a multiprofessional study group from different centers (Arbeitsgemeinschaft Neurodermitisschulung für Erwachsene [ARNE]). Patients were randomly allocated to the intervention or waiting control groups. Study visits were performed at baseline and after 1 year (1 year of follow-up). Primary outcomes were defined as a decrease in (1) "catastrophizing cognitions" with respect to itching (Juckreiz-Kognitions-Fragebogen questionnaire), (2) "social anxiety" (Marburger Hautfragebogen questionnaire), (3) subjective burden by symptoms of the disease (Skindex-29 questionnaire), and (4) improvement of disease signs and symptoms assessed by using the SCORAD index at 1 year of follow-up. Data were analyzed on an intention-to-treat basis. RESULTS: At 1 year of follow-up, patients from the intervention group (n = 168) showed a significantly better improvement compared with the waiting group (n = 147) in the following defined primary study outcomes: coping behavior with respect to itching (P < .001), quality of life assessed by using the Skindex-29 questionnaire (P < .001), and the SCORAD index (P < .001). CONCLUSIONS: This is the first randomized, controlled multicenter study on patient education in adult AD. The ARNE training program shows significant beneficial effects on a variety of psychosocial parameters, as well as AD severity.

Authors with CRIS profile

Involved external institutions

Vital Klinik GmbH & Co. KG Germany (DE) Universität Leipzig Germany (DE) Klinikum Darmstadt Germany (DE) Technische Universität Dresden Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Technische Universität München (TUM) Germany (DE) Dermatologikum Hamburg Germany (DE) Hautmedizin Bad Soden Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Elbe Kliniken Stade-Buxtehude Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Neurodermitis-Akademie Hessen Germany (DE) Justus-Liebig-Universität Gießen Germany (DE)

How to cite

APA:

Heratizadeh, A., Werfel, T., Wollenberg, A., Abraham, S., Plank-Habibi, S., Schnopp, C.,... Kupfer, J. (2017). Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial. Journal of Allergy and Clinical Immunology, 140(3), 845-853.e3. https://doi.org/10.1016/j.jaci.2017.01.029

MLA:

Heratizadeh, Annice, et al. "Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial." Journal of Allergy and Clinical Immunology 140.3 (2017): 845-853.e3.

BibTeX: Download