Strick R, Strissel P, Baylin SB, Chiappinelli KB (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 5
Journal Issue: 5
DOI: 10.1080/2162402X.2015.1122160
Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.
APA:
Strick, R., Strissel, P., Baylin, S.B., & Chiappinelli, K.B. (2016). Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors. OncoImmunology, 5(5). https://doi.org/10.1080/2162402X.2015.1122160
MLA:
Strick, Reiner, et al. "Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors." OncoImmunology 5.5 (2016).
BibTeX: Download