Long-term clinical outcome after implantation of the self-expandable STENTYS stent in a large, multicenter cohort

Gaede L, Liebetrau C, Doerr O, Blumenstein J, Elsaesser A, Hamm CW, Moellmann H, Schlundt C, Nef HM, Achenbach S (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Coronary Artery Disease Lippincott, Williams & Wilkins

Book Volume: 28

Pages Range: 588-596

Journal Issue: 7

DOI: 10.1097/MCA.0000000000000533

Abstract

OBJECTIVE: The objective of the study was to retrospectively evaluate the long-term clinical outcome after implantation of the self-expandable (SE) STENTYS stent in a large multicenter cohort. BACKGROUND: Incomplete stent apposition is known to cause higher rates of myocardial infarction (MI) and stent thrombosis. Because of its self-expanding features, the SE STENTYS stent adapts to the vessel wall and is therefore expected to minimize malapposition and therefore the rates of MI and stent thrombosis. PATIENTS AND METHODS: Treatment with a total of 351 SE coronary stents was attempted in 314 patients of a cohort from three German institutions between 2011 and 2015. Technical success was achieved with 331/351 (94%) stents. Patients treated successfully with SE stents (n=298) were followed up using the primary outcome measure of target lesion failure (TLF), a combined endpoint of cardiac mortality, recurrent target vessel MI, acute stent thrombosis, and clinically driven target lesion revascularization. Follow-up was complete in 268/298 (90%) patients with a median follow-up period of 2.5 (interquartile range: 1.4-3.3) years. RESULTS: TLF occurred in 54/298 (18%) patients. Event rates were 7.5% for cardiac mortality, 11.6% for target vessel MI, and 5.2% for clinically driven target lesion revascularization. Acute stent thrombosis occurred in 2/298 (0.7%). Overall, stent thrombosis had an incidence of 2.6% within the follow-up period. ST-elevation MI at baseline (P=0.02) and a dual antiplatelet therapy with clopidogrel for only 6 months (P=0.04) were the only clinical factors linked to the absence of TLF. CONCLUSION: Technical success of SE coronary stent implantation in an all-comer cohort of patients was high, although the rate of TLF and stent thrombosis during long-term follow-up was also relatively high.

Authors with CRIS profile

Christian Schlundt Department of Medicine 2 – Cardiology and Angiology Stephan Achenbach Department of Medicine 2 – Cardiology and Angiology

Involved external institutions

St.-Johannes-Hospital DE Germany (DE) Kerckhoff-Klinik DE Germany (DE) Justus-Liebig-Universität Gießen DE Germany (DE) Carl von Ossietzky Universität Oldenburg DE Germany (DE)

How to cite

APA:

Gaede, L., Liebetrau, C., Doerr, O., Blumenstein, J., Elsaesser, A., Hamm, C.W.,... Achenbach, S. (2017). Long-term clinical outcome after implantation of the self-expandable STENTYS stent in a large, multicenter cohort. Coronary Artery Disease, 28(7), 588-596. https://doi.org/10.1097/MCA.0000000000000533

MLA:

Gaede, Luise, et al. "Long-term clinical outcome after implantation of the self-expandable STENTYS stent in a large, multicenter cohort." Coronary Artery Disease 28.7 (2017): 588-596.

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