Joint Effects of the Epigenetic Alteration of Neurotrophins and Cytokine Signaling: A Possible Exploratory Model of Affective Symptoms in Alcohol-Dependent Patients?
Heberlein A, Schuster R, Kleimann A, Groh A, Kordon A, Opfermann B, Lichtinghagen R, Groschl M, Kornhuber J, Bleich S, Frieling H, Hillemacher T (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 52
Pages Range: 277-281
Journal Issue: 3
Abstract
Aims: Neurotrophins have been linked to the symptomatology of alcohol dependence. We aimed to investigate a possible association between the methylation of the promoters of both neurotrophins, the serum levels of the cytokines and core symptoms of alcohol dependence as withdrawal severity and anxiety. Methods: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients. Results: Mean methylation of the promoter of the BDNF gene was significantly associated with the TNF-α serum levels and the CIWA-score during withdrawal (P < 0.001). Moreover, mean methylation of the NGF I promoter was significantly associated with the IL-6 serum levels and STAI-I score during withdrawal (P < 0.001). Conclusion: Our results suggest an association between the epigenetic regulation of both neurotrophins, BDNF and NGF, cytokine release and the symptomatology of alcohol dependence. They imply that changes in the methylation of neurotrophins may contribute to the symptomatology of alcohol dependence by affecting relevant downstream signaling cascades.
Authors with CRIS profile
Involved external institutions
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Oberbergklinik Schwarzwald
Germany (DE)
Medizinischer Dienst der Krankenversicherungen Niedersachsen
Germany (DE)
celerion
Switzerland (CH)
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Oberbergklinik Schwarzwald
Germany (DE)
Medizinischer Dienst der Krankenversicherungen Niedersachsen
Germany (DE)
celerion
Switzerland (CH)
How to cite
APA:
Heberlein, A., Schuster, R., Kleimann, A., Groh, A., Kordon, A., Opfermann, B.,... Hillemacher, T. (2017). Joint Effects of the Epigenetic Alteration of Neurotrophins and Cytokine Signaling: A Possible Exploratory Model of Affective Symptoms in Alcohol-Dependent Patients? Alcohol and Alcoholism, 52(3), 277-281. https://doi.org/10.1093/alcalc/agw100
MLA:
Heberlein, Annemarie, et al. "Joint Effects of the Epigenetic Alteration of Neurotrophins and Cytokine Signaling: A Possible Exploratory Model of Affective Symptoms in Alcohol-Dependent Patients?" Alcohol and Alcoholism 52.3 (2017): 277-281.
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