SoxE factors: Transcriptional regulators of neural differentiation and nervous system development.

Weider M, Wegner M (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Seminars in Cell & Developmental Biology Elsevier

Pages Range: 35-42.

Journal Issue: 63

DOI: 10.1016/j.semcdb.2016.08.013

Abstract

Sox8, Sox9 and Sox10 represent the three vertebrate members of the SoxE subclass of high-mobility-group domain containing Sox transcription factors. They play important roles in the peripheral and central nervous systems as regulators of stemness, specification, survival, lineage progression, glial differentiation and homeostasis. Functions are frequently overlapping, but sometimes antagonistic. SoxE proteins dynamically interact with transcriptional regulators, chromatin changing complexes and components of the transcriptional machinery. By establishing regulatory circuits with other transcription factors and microRNAs, SoxE proteins perform divergent functions in several cell lineages of the vertebrate nervous system, and at different developmental stages in the same cell lineage. The underlying molecular mechanisms are the topic of this review.

Authors with CRIS profile

Matthias Weider Lehrstuhl für Biochemie und Pathobiochemie Michael Wegner Lehrstuhl für Biochemie und Pathobiochemie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center) Interdisziplinäres Zentrum für Klinische Forschung

How to cite

APA:

Weider, M., & Wegner, M. (2017). SoxE factors: Transcriptional regulators of neural differentiation and nervous system development. Seminars in Cell & Developmental Biology, 63, 35-42.. https://doi.org/10.1016/j.semcdb.2016.08.013

MLA:

Weider, Matthias, and Michael Wegner. "SoxE factors: Transcriptional regulators of neural differentiation and nervous system development." Seminars in Cell & Developmental Biology 63 (2017): 35-42.

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