Gusowski K, Bures AK, Kuld S, Weiland AC, Gawlik A, Streber R, Tallner A, Pfeifer K, Flachenecker P (2018)
Publication Language: English
Publication Type: Conference contribution, Conference Contribution
Publication year: 2018
Conference Proceedings Title: Multiple Sclerosis Journal
Background: Persons with MS (PwMS)
benefit from inpatient multidisciplinary rehabilitatoin with regard to
fatigue and motor performance. To sustain the effects, an internet-based
training program was introduced during rehabilitation and performed for
3 months thereafter. Primary endpoint analysis showed that the
internet-based training could maintain the improvements for up to 6
month.
Objectives: In order to determine which PwMS revealed
the most pronounced respoonse to therapy, we performed a subgroup
analysis by stratifying PwMS according to baseline performance.
Methods:
34 PwMS participated in the training group and 30 in control group.
Performance oriented mobility assessment (POMA) for the rist of fall,
10m-walk-test (10MWT) and 2-minute-walking test (2MWT) were measured at
the beginning of the inpatient rehabiliation program (T0), at discharge
(T1) and 3 month after training (T2), Fatigue (WEImuS) and quality of
life (MSIS-29 and EQ-5d) were measured at T0, T1, T2 and 6 month after
discharge (T3). Siubgroups were divided in low and high performance
(POMA and EQ-5d VAS: median value at T0, 10MWT: 7 sec, 14 steps; 2MWT
168m.
Results The effects of rehabitation on fatigue and
quality of life were maintained at T2 and T3 in the training group.
Subgroup analysis of omtor performance at T2 showed a significant
benefit in 10MWT and POMA in the low performance group, whereas in 2MWT,
the high performance subgroup remained highly significant. The EQ-5d
VAS demonstrated highly significant changes in the whole training group
as well as in the subgroup with low performance.
Discussion:
Statistically and clinically meaningful improvements of fatigue, QoL and
motor performance were demonstrated after 3 months of internet-based
training, with effects being more pronounced in more affected pwMS. An
internet-based training program may be effective to maintain the
positive effects of inpatient rehabilitation for at least up to 6
months.
APA:
Gusowski, K., Bures, A.-K., Kuld, S., Weiland, A.-C., Gawlik, A., Streber, R.,... Flachenecker, P. (2018). MS-int@kt: subgroup analysis of an internet-based training on fatigue, quality of life and gait. In Multiple Sclerosis Journal. Amsterdam, NL.
MLA:
Gusowski, Klaus, et al. "MS-int@kt: subgroup analysis of an internet-based training on fatigue, quality of life and gait." Proceedings of the Annual RIMS 2018 Conference, Amsterdam 2018.
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