The Fuhrman grading system has no prognostic value in patients with nonsarcomatoid chromophobe renal cell carcinoma

Steffens S, Janssen M, Roos FC, Becker F, Steinestel J, Abbas M, Steinestel K, Wegener G, Siemer S, Thueroff JW, Hofmann R, Stoeckle M, Schrader M, Hartmann A, Hasenfus A, Kuczyk MA, Junker K, Schrader AJ (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Human Pathology WB Saunders

Publisher: WB Saunders

Book Volume: 45

Pages Range: 2411-6

Journal Issue: 12

DOI: 10.1016/j.humpath.2014.08.002

Abstract

The prognostic value of the Fuhrman nuclear grading system has been questioned for chromophobe renal cell carcinoma (chRCC) because this subtype frequently displays nuclear and nucleolar pleomorphism. The present study reevaluates this grading system in a series of patients with nonsarcomatoid chRCC. We identified 176 patients (3.6%) with nonsarcomatoid chRCC in a total of 4897 patients who underwent surgery for renal cell carcinoma at 5 centers in Germany between 1990 and 2010. The mean follow-up was 51.1 months. The 3 groups (G1 versus G2 versus G3/4) were comparable in terms of age, sex, tumor diameter, and lymph node metastasis. They only differed significantly in tumor stage (P = .01) and the incidence of synchronous visceral metastasis (P = .04). The 5-year cancer-specific survival rates were 84.4% for G1 (n = 32), 84.3% for G2 (n = 108), and 74.1% for G3/4 tumors (n = 33) (P = .58). Accordingly, multivariate analysis including age, sex, tumor stage, and metastatic disease did not identify Fuhrman grading as an independent predictor of cancer-specific survival in patients with chRCC (P = .4). We were able to demonstrate in a large multicenter cohort that the Fuhrman grading system does not qualify as a prognostic tool in patients with chRCC.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Gottfried Wilhelm Leibniz Universität Hannover DE Germany (DE) Universität des Saarlandes (UdS) DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Zentrum am Boxberg DE Germany (DE) Universität Ulm DE Germany (DE) Bundeswehrkrankenhaus Ulm DE Germany (DE) Philipps-Universität Marburg DE Germany (DE)

How to cite

APA:

Steffens, S., Janssen, M., Roos, F.C., Becker, F., Steinestel, J., Abbas, M.,... Schrader, A.J. (2014). The Fuhrman grading system has no prognostic value in patients with nonsarcomatoid chromophobe renal cell carcinoma. Human Pathology, 45(12), 2411-6. https://doi.org/10.1016/j.humpath.2014.08.002

MLA:

Steffens, Sandra, et al. "The Fuhrman grading system has no prognostic value in patients with nonsarcomatoid chromophobe renal cell carcinoma." Human Pathology 45.12 (2014): 2411-6.

BibTeX: Download