DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia

Van Der Sligte NE, Krumbholz M, Pastorczak A, Scheijen B, Tauer JT, Nowasz C, Sonneveld E, De Bock GH, Meeuwsen-De Boer TGJ, Van Reijmersdal S, Kuiper RP, Bradtke J, Metzler M, Suttorp M, De Bont ESJM, Van Leeuwen FN (2014)

Publication Type: Journal article

Publication year: 2014

Journal

British Journal of Haematology Wiley-Blackwell

Publisher: Wiley-Blackwell

Book Volume: 166

Pages Range: 250-3

Journal Issue: 2

DOI: 10.1111/bjh.12850

Abstract

Early recognition of children with chronic phase chronic myeloid leukaemia (CML-CP) at risk for developing a lymphoid blast crisis (LyBC) is desirable, because therapy options in CML-LyBC are limited. We used Multiplex Ligation-dependent Probe Amplification to determine whether B-cell lymphoid leukaemia-specific copy number alterations (CNAs) (e.g. IKZF1, PAX5, CDKN2A deletions) could be detected in CML-CP and may be used to predict disease progression to LyBC. CNAs were detected in all patients with CML-LyBC, but in none of the 77 patients with CML-CP. Based on this study we conclude that CNAs remain a hallmark of disease progression.

Authors with CRIS profile

Manuela Krumbholz Department of Paediatrics and Adolescent Medicine Markus Metzler Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie

Involved external institutions

University of Groningen / Rijksuniversiteit Groningen NL Netherlands (NL) Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE) Dutch Childhood Oncology Group NL Netherlands (NL) Radboud University Nijmegen NL Netherlands (NL) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE)

How to cite

APA:

Van Der Sligte, N.E., Krumbholz, M., Pastorczak, A., Scheijen, B., Tauer, J.T., Nowasz, C.,... Van Leeuwen, F.N. (2014). DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia. British Journal of Haematology, 166(2), 250-3. https://doi.org/10.1111/bjh.12850

MLA:

Van Der Sligte, Naomi E., et al. "DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia." British Journal of Haematology 166.2 (2014): 250-3.

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