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DCE-MRI of the breast in a stand-alone setting outside a complementary strategy - results of the TK-study

Kaiser CG, Reich C, Dietzel M, Baltzer PAT, Krammer J, Wasser K, Schoenberg SO, Kaiser WA (2015)

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Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 25

Pages Range: 1793-800

Journal Issue: 6

DOI: 10.1007/s00330-014-3580-4

Abstract

To evaluate the accuracy of MRI of the breast (DCE-MRI) in a stand-alone setting with extended indications.According to the inclusion criteria, breast specialists were invited to refer patients to our institution for DCE-MRI. Depending on the MR findings, patients received either a follow-up or biopsy. Between 04/2006 and 12/2011 a consecutive total of 1,488 women were prospectively examined.Of 1,488 included patients, 393 patients were lost to follow-up, 1,095 patients were evaluated. 124 patients were diagnosed with malignancy by DCE-MRI (76 TP, 48 FP, 971 TN, 0 FN cases). Positive cases were confirmed by histology, negative cases by MR follow-ups or patient questionnaires over the next 5 years in 1,737 cases (sensitivity 100 %; specificity 95.2 %; PPV 61.3 %; NPV 100 %; accuracy 95.5 %). For invasive cancers only (DCIS excluded), the results were 63 TP; 27 FP; 971 TP and 0 FN (sensitivity 100 %; specificity 97.2 %; PPV 70 %; NPV 100 %; accuracy 97.5 %).The DCE-MRI indications tested imply that negative results in DCE-MRI reliably exclude cancer. The results were achieved in a stand-alone setting (single modality diagnosis). However, these results are strongly dependent on reader experience and adequate technical standards as prerequisites for optimal diagnoses.o DCE-MRI of the breast has a high accuracy in finding breast cancer. o The set of indications for DCE-MRI of the breast is still very limited. o DCE-MRI can achieve a high accuracy in a 'screening-like' setting. o Accuracy of breast DCE-MRI is strongly dependent on technique and reader experience. o A negative DCE-MRI effectively excludes cancer.

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How to cite

APA:

Kaiser, C.G., Reich, C., Dietzel, M., Baltzer, P.A.T., Krammer, J., Wasser, K.,... Kaiser, W.A. (2015). DCE-MRI of the breast in a stand-alone setting outside a complementary strategy - results of the TK-study. European Radiology, 25(6), 1793-800. https://doi.org/10.1007/s00330-014-3580-4

MLA:

Kaiser, Clemens G., et al. "DCE-MRI of the breast in a stand-alone setting outside a complementary strategy - results of the TK-study." European Radiology 25.6 (2015): 1793-800.

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