Oligoclonal bands predict multiple sclerosis in children with optic neuritis

Heussinger N, Kontopantelis E, Gburek-Augustat J, Jenke A, Vollrath G, Korinthenberg R, Hofstetter P, Meyer S, Brecht I, Kornek B, Herkenrath P, Schimmel M, Wenner K, Haeusler M, Lutz S, Karenfort M, Blaschek A, Smitka M, Karch S, Piepkorn M, Rostasy K, Luecke T, Weber P, Trollmann R, Klepper J, Haeussler M, Hofmann R, Weissert R, Merkenschlager A, Buttmann M (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 77

Pages Range: 1076-82

Journal Issue: 6

DOI: 10.1002/ana.24409

Abstract

We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow-up of 4.0 years. Multiple Cox proportional-hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR] = 5.94, 95% confidence interval [CI] = 3.39-10.39, p < 0.001), presence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR = 3.69, 95% CI = 2.32-5.86, p < 0.001), and age (HR = 1.08 per year of age, 95% CI = 1.02-1.13, p = 0.003) as independent predictors of conversion, whereas sex and laterality (unilateral vs bilateral) had no influence. Combined cMRI and OCB positivity indicated a 26.84-fold higher HR for developing MS compared to double negativity (95% CI = 12.26-58.74, p < 0.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON.

Authors with CRIS profile

Involved external institutions

Justus-Liebig-Universität Gießen Germany (DE) Universität Regensburg Germany (DE) Universität Leipzig Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Klinikum Aschaffenburg Germany (DE) University of Manchester United Kingdom (GB) Universitätsklinikum Tübingen Germany (DE) Universität Witten/Herdecke Germany (DE) Universität Rostock Germany (DE) Universitätsklinikum Freiburg Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Medizinische Universität Wien Austria (AT) Universität zu Köln Germany (DE) Universitätsklinikum Augsburg Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) Universität Duisburg-Essen (UDE) Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Technische Universität Dresden Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Kinder- und Jugendkrankenhaus "Auf der Bult" Germany (DE) Medizinische Universität Innsbruck Austria (AT) Ruhr-Universität Bochum (RUB) Germany (DE) Universitäts-Kinderspital beider Basel (UKBB) Switzerland (CH)

How to cite

APA:

Heussinger, N., Kontopantelis, E., Gburek-Augustat, J., Jenke, A., Vollrath, G., Korinthenberg, R.,... Buttmann, M. (2015). Oligoclonal bands predict multiple sclerosis in children with optic neuritis. Annals of Neurology, 77(6), 1076-82. https://doi.org/10.1002/ana.24409

MLA:

Heussinger, Nicole, et al. "Oligoclonal bands predict multiple sclerosis in children with optic neuritis." Annals of Neurology 77.6 (2015): 1076-82.

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