Usage of 1,3-?-D-Glucan for Early Detection of Invasive Mycoses and Outcome Parameter in Immunocompromised Critically Ill Patients
Lahmer T, Held J, Rasch S, Schnappauf C, Beitz A, Schmid RM, Huber W (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 181
Pages Range: 815-821
Journal Issue: 11-12
DOI: 10.1007/s11046-016-0061-0
Abstract
Invasive fungal disease (IFD) remains a significant cause of morbidity and mortality in critically ill patients.Examination of 1,3-?-D-glucan (BDG) for IFD and as outcome parameter in immunocompromised critically ill patients with septic shock.Thirty-two (69 %) out of 46 included patients had BDG beyond the cutoff of >80 pg/ml (mean 320 pg/ml). Twelve (37 %) had findings of Aspergillus spp. in BAL (mean BDG 413 pg/ml). EORTC/MSG guidelines classified these as probable invasive aspergillosis (IA)/IFD. Five (16 %) had candidaemia (mean BDG level 361 pg/ml). Sensitivity of 78 % (95 % CI 58-88 %) and specificity of 68 % (95 % CI 52-77 %) for IFD were found on the BDG Fungitell assay. In detail, a sensitivity of 73 % (95 % 58-84 %) and specificity of 83 % (95 % CI 68-93 %) for IA and a sensitivity of 77 % (CI 95 % 62-87 %) and specificity 53 % (95 % CI 37-73 %) for candidaemia were found. APACHE II, SOFA score and mortality rate were in the elevated BDG group significantly altered (26 vs. 21, p < 0.003; 15 vs. 13, p < 0.006; 72 vs. 50 %, p < 0.004).1,3-?-D-glucan assay is helpful for early detection of IFD; moreover, elevated BDG levels can be used as a predictor for outcome in immunocompromised critically ill patients as presented in our study.
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Germany (DE)How to cite
APA:
Lahmer, T., Held, J., Rasch, S., Schnappauf, C., Beitz, A., Schmid, R.M., & Huber, W. (2016). Usage of 1,3-?-D-Glucan for Early Detection of Invasive Mycoses and Outcome Parameter in Immunocompromised Critically Ill Patients. Mycopathologia, 181(11-12), 815-821. https://doi.org/10.1007/s11046-016-0061-0
MLA:
Lahmer, Tobias, et al. "Usage of 1,3-?-D-Glucan for Early Detection of Invasive Mycoses and Outcome Parameter in Immunocompromised Critically Ill Patients." Mycopathologia 181.11-12 (2016): 815-821.
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