Genetic risk factors for ovarian cancer and their role for endometriosis risk

Burghaus S, Fasching P, Haeberle L, Rübner M, Buechner K, Blum S, Engel A, Ekici AB, Hartmann A, Hein A, Beckmann M, Renner S (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Gynecologic Oncology Elsevier

Book Volume: 145

Pages Range: 142-147

Journal Issue: 1

DOI: 10.1016/j.ygyno.2017.02.022

Abstract

Several genetic variants have been validated as risk factors for ovarian cancer. Endometriosis has also been described as a risk factor for ovarian cancer. Identifying genetic risk factors that are common to the two diseases might help improve our understanding of the molecular pathogenesis potentially linking the two conditions.In a hospital-based case-control analysis, 12 single nucleotide polymorphisms (SNPs), validated by the Ovarian Cancer Association Consortium (OCAC) and the Collaborative Oncological Gene-environment Study (COGS) project, were genotyped using TaqMan® OpenArray(TM) analysis. The cases consisted of patients with endometriosis, and the controls were healthy individuals without endometriosis. A total of 385 cases and 484 controls were analyzed. Odds ratios and P values were obtained using simple logistic regression models, as well as from multiple logistic regression models with adjustment for clinical predictors.rs11651755 in HNF1B was found to be associated with endometriosis in this case-control study. The OR was 0.66 (95% CI, 0.51 to 0.84) and the P value after correction for multiple testing was 0.01. None of the other genotypes was associated with a risk for endometriosis.As rs11651755 in HNF1B modified both the ovarian cancer risk and also the risk for endometriosis, HNF1B may be causally involved in the pathogenetic pathway leading from endometriosis to ovarian cancer.

Authors with CRIS profile

Stefanie Burghaus Department of Obstetrics and Gynaecology Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Matthias Rübner Department of Obstetrics and Gynaecology Anne Engel Professur für Translationale Frauenheilkunde und Geburtshilfe Arif Bülent Ekici Institute of Human Genetics Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Alexander Hein Department of Obstetrics and Gynaecology Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Stefan Renner Department of Obstetrics and Gynaecology

How to cite

APA:

Burghaus, S., Fasching, P., Haeberle, L., Rübner, M., Buechner, K., Blum, S.,... Renner, S. (2017). Genetic risk factors for ovarian cancer and their role for endometriosis risk. Gynecologic Oncology, 145(1), 142-147. https://doi.org/10.1016/j.ygyno.2017.02.022

MLA:

Burghaus, Stefanie, et al. "Genetic risk factors for ovarian cancer and their role for endometriosis risk." Gynecologic Oncology 145.1 (2017): 142-147.

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