Proposal of a clinical response score and predictors of clinical response to 2 years of GH replacement therapy in adult GH deficiency
Schneider HJ, Buchfelder M, Wallaschofski H, Luger A, Johannsson G, Kann PH, Mattsson A (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 173
Pages Range: 843-51
Journal Issue: 6
DOI: 10.1530/EJE-15-0305
Abstract
There is no single clinical marker to reliably assess the clinical response to growth hormone replacement therapy (GHRT) in adults with growth hormone deficiency (GHD). The objective of this study was to propose a clinical response score to GHRT in adult GHD and to establish clinical factors that predict clinical response.This was a prospective observational cohort study from the international KIMS database (Pfizer International Metabolic Database).We included 3612 adult patients with GHD for proposing the response score and 844 patients for assessing predictors of response. We propose a clinical response score based on changes in total cholesterol, waist circumference and QoL-AGHDA quality of life measurements after 2 years of GHRT. A score point was added for each quintile of change in each variable, resulting in a sum score ranging from 3 to 15. For clinical response at 2 years, we analysed predictors at baseline and after 6 months using logistic regression analyses.In a baseline prediction model, IGF1, QoL-AGHDA, total cholesterol and waist circumference predicted response, with worse baseline parameters being associated with a favourable response (AUC 0.736). In a combined baseline and 6-month prediction model, baseline QoL-AGHDA, total cholesterol and waist circumference, and 6-month change in waist circumference were significant predictors of response (AUC 0.815).A simple clinical response score might be helpful in evaluating the success of GHRT. The baseline prediction model may aid in the decision to initiate GHRT and the combined prediction model may be helpful in the decision to continue GHRT.
Authors with CRIS profile
Involved external institutions
University of Gothenburg / Göteborgs universitet
Sweden (SE)
Pfizer AB Sweden
Sweden (SE)
Philipps-Universität Marburg
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Universität Greifswald
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
Sweden (SE)
Pfizer AB Sweden
Sweden (SE)
Philipps-Universität Marburg
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Universität Greifswald
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
How to cite
APA:
Schneider, H.J., Buchfelder, M., Wallaschofski, H., Luger, A., Johannsson, G., Kann, P.H., & Mattsson, A. (2015). Proposal of a clinical response score and predictors of clinical response to 2 years of GH replacement therapy in adult GH deficiency. European Journal of Endocrinology, 173(6), 843-51. https://doi.org/10.1530/EJE-15-0305
MLA:
Schneider, Harald J., et al. "Proposal of a clinical response score and predictors of clinical response to 2 years of GH replacement therapy in adult GH deficiency." European Journal of Endocrinology 173.6 (2015): 843-51.
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